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pathways's Introduction

A compilation of pathway gene sets

DOI

This repository compiles pathway gene sets for inclusion into the Rephetio hetnet. Pathways are compiled from WikiPathways and Pathway Commons into a user-friendly TSV (data/pathways.tsv). The resources extracted from Pathway Commons are the Pathway Interaction Database (PID) and Reactome.

Only protein-coding human genes (as Entrez Gene IDs) are included. See the corresponding Thinklab discussion for more information.

Execute the merge-resources.ipynb python notebook to rebuild the dataset.

License

All original content in this repository is released as CC0 1.0 (public domain). WikiPathways data is licensed as CC BY 3.0. Reactome data is licensed as CC BY 4.0. PID data is in the public domain.

Reuse of the Pathway Commons download ([download/Pathway Commons.7.All.GSEA.hgnc.gmt](download/Pathway Commons.7.All.GSEA.hgnc.gmt)) is subject to the license terms of each contributing database.

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pathways's Issues

Where does Pathway identifier come from?

While I validate Hetionet by comparing with original data sources, I stuck with Pathway.
What is the meaning of "Reactome via Pathway Commons"?
Pathway nodes in Hetionet have “PC7_digits” patterned ids.
However, I cannot find such id neither from Pathway Commons nor Reactome which have “R-HSA-digis” style ids.
I wonder if Pathway Commons is used as it is not in the list and how I can find the original data.

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