TRBD gene about stitchr HOT 2 CLOSED

Hello,

You're welcome (and thanks)!

There's no option for D genes because it doesn't really make a difference to stitchr. In a rearranged receptor all of the D gene residues are wholly contained inside the CDR3, so when you give stitchr the CDR3 it already has all the D sequence included.

(Just for the record the TRBD alleles do differ slightly. However they're very short and often pretty nibbled during VDJ recombination so it's often impossible to tell which was used - hence why D gene assignment isn't as much of a thing in TCR research like it is for BCRs.)

Cheers,
Jamie

from stitchr.

Thank you so much for the fast reply! It is very clear!

from stitchr.