The directory java contains source files for the AnyBURL algorithm with the original license preserved. Some changes have been applied to the source to address bugs and other small issues.

The java code must be compiled before running the example scripts here, to compile the code ensure that you have Java installed (we recommend OpenJDK v14 and Apache Maven v3.9.4).

To compile the java code;

$ make build-java

We recommend installing the code in a python virtualenv. Once you have a virtualenv set up, the code can be installed with

pip install -e '.[dev]'

and tests can be run with tox

tox

and linters can be run with the shortcut

make lint

Train AnyBURL using the graph provided in data/triples.txt

anyburl-train data

results are written to a results directory.

Generate rules from the trained AnyBURL artefacts in results

anyburl-predict data

further results are written to the results directory.

Run this command to create a list of evidence chains for "Parkinson disease" treatments (defined in data/parkinson_disease_predicted_treatments.txt), the output is written to evidence-chains.jsonl.

healx-chains \
    data \
    results \
    results/predict-1000 \
    results/predict-explanation \
    --predictions-filter-file data/parkinson-disease-filter/predictions.txt \
    --explanations-filter-file data/parkinson-disease-filter/prioritised-edge-types.txt

Results are written to an evidence chains file results/evidence-chains.jsonl in the JSONL format. Each line contains a generated "chain" prediction with the following example structure

{
  "prediction": "methixene_COMPOUND",
  "prediction_score": 0.08924107199497017,
  "start_node": "methixene_COMPOUND",
  "end_node": "parkinson_disease_DISEASE",
  "metapath": [
    {
      "label": "COMPOUND_inhibits_GENE",
      "reversed": false
    },
    {
      "label": "DISEASE_associates_GENE",
      "reversed": true
    }
  ],
  "path_score": 0.005949453701297636,
  "path": [
    "methixene_COMPOUND",
    "htr2c_GENE",
    "parkinson_disease_DISEASE"
  ]
}

we can expect to find thousands of chains in this file.

Run this command (after creating the evidence chains file) to filter chains by gene and pathway for "Parkinson disease".

healx-filter \
    results/evidence-chains.jsonl \
    data/parkinson-disease-filter/genes.txt \
    data/parkinson-disease-filter/pathways.txt \
    data/parkinson-disease-filter/predictions-short-list.txt \
    data/parkinson-disease-filter/prioritised-edge-types.txt \
    --filtered-evidence-chains-file filtered-evidence-chains.txt

which will produce a filtered evidence chains file in text format, filtered-evidence-chains.txt - one line per text chain. An example of one of the lines from this file are

AMANTADINE inhibits CHRNA3 participates NEUROACTIVE_LIGAND-RECEPTOR_INTERACTION involves CABERGOLINE in_trial_for PARKINSON_DISEASE

.