pkr Shinyhttps://asan.shinyapps.io/pkrshinypkr Shinyis open to everyone. We are happy to take your input. Please fork the repo, modify the codes and submit a pull request. https://github.com/asancpt/pkrshiny- We are actively developing R pacakges, Shiny Apps, and Edison Science Apps regarding clinical pharmacology and pharmacometrics. Please check here. https://asancpt.github.io/softwares
install.packages("pkr")
library(pkr)
NCA(Theoph, "Subject", "Time", "conc", dose=320, uConc="mg/L")pkrpackage help https://cran.r-project.org/web/packages/pkr/pkr.pdf
Theoph: Oral 320 mg (N=12) http://stat.ethz.ch/R-manual/R-devel/library/datasets/html/Theoph.htmlIndometh: IV 25 mg (N=6) http://stat.ethz.ch/R-manual/R-devel/library/datasets/html/Indometh.htmlsd_oral_richpk: Oral 5000mg (N=50) https://github.com/dpastoor/PKPDdatasetssd_iv_rich_pkpd: IV diverse dosing (N=60) https://github.com/dpastoor/PKPDdatasets
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.
Chang W, Cheng J, Allaire J, Xie Y, McPherson J (2020). shiny: Web Application Framework for R. R package version 1.4.0.1, https://CRAN.R-project.org/package=shiny.
Bae K, Lee JE (2018). pkr: Pharmacokinetics in R. R package version 0.1.2, https://CRAN.R-project.org/package=pkr.
Allaire J, Horner J, Xie Y, Marti V, Porte N (2019). markdown: Render Markdown with the C Library 'Sundown'. R package version 1.1, https://CRAN.R-project.org/package=markdown.
Grosjean P, Ibanez F (2018). pastecs: Package for Analysis of Space-Time Ecological Series. R package version 1.3.21, https://CRAN.R-project.org/package=pastecs.
Wickham H (2016). ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York. ISBN 978-3-319-24277-4, https://ggplot2.tidyverse.org.
Wickham H, François R, Henry L, Müller K (2020). dplyr: A Grammar of Data Manipulation. https://dplyr.tidyverse.org, https://github.com/tidyverse/dplyr.
Wickham H, Henry L (2020). tidyr: Tidy Messy Data. R package version 1.0.2, https://CRAN.R-project.org/package=tidyr.
Gohel D, Skintzos P (2019). ggiraph: Make 'ggplot2' Graphics Interactive. R package version 0.7.0, https://CRAN.R-project.org/package=ggiraph.
Chang W, Borges Ribeiro B (2018). shinydashboard: Create Dashboards with 'Shiny'. R package version 0.7.1, https://CRAN.R-project.org/package=shinydashboard.
Xie Y (2020). knitr: A General-Purpose Package for Dynamic Report Generation in R. R package version 1.28, https://yihui.org/knitr/.
Xie Y (2015). Dynamic Documents with R and knitr, 2nd edition. Chapman and Hall/CRC, Boca Raton, Florida. ISBN 978-1498716963, https://yihui.org/knitr/.
Xie Y (2014). “knitr: A Comprehensive Tool for Reproducible Research in R.” In Stodden V, Leisch F, Peng RD (eds.), Implementing Reproducible Computational Research. Chapman and Hall/CRC. ISBN 978-1466561595, http://www.crcpress.com/product/isbn/9781466561595.
## ─ Session info ───────────────────────────────────────────────────────────────
## setting value
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## os Ubuntu 18.04.4 LTS
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## tz Etc/UTC
## date 2020-03-12
##
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