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Feature-derived graph regularized matrix factorization for predicting drug side effects

基本情報

タイトル:Feature-derived graph regularized matrix factorization for predicting drug side effects
著者:
出版日: 26 April 2018
学会/ジャーナル: Neurocomputing

1. どんなもの?

副作用予測のためのmatrix factroizationの改良

2. 先行研究と比べてどこがすごい?

既存手法の精度向上

3. 技術や手法のキモはどこ?

医薬品の類似性による正則化項を追加

4. どうやって有効だと検証した?

CV using Liu's dataset (副作用はSIDERから取ってるので実質SIDER)
External validation using SIDER dataset after Liu's dataset construction

  • top1000 predictionsを取ってきて、何個あたってるかで検証

20 runs of 5-fold CV

5. 議論はある?

パラメータはtestでベストなAUPRが出るものを使ってる

6. 次に読むべき論文は?

A Recommender System Approach for Predicting Drug Side Effects

基本情報

タイトル:A Recommender System Approach for Predicting Drug Side Effects
著者:
出版日: 8-13 July 2018
学会/ジャーナル: IEEE

1. どんなもの?

matrix factorizationを副作用予測に応用

2. 先行研究と比べてどこがすごい?

PPNに対して精度向上

3. 技術や手法のキモはどこ?

副作用予測を推薦問題と捉え、matrix factorizationを応用

4. どうやって有効だと検証した?

PR-AUC for hold-out test set.
Parameter tuning using 10-fold CV with train set.

5. 議論はある?

データ多くないのにhold-out
実際に予測が当たるのかSIDER以降のデータで検証した方が良さげ

6. 次に読むべき論文は?

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