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Feature-derived graph regularized matrix factorization for predicting drug side effects
基本情報
タイトル:Feature-derived graph regularized matrix factorization for predicting drug side effects
著者:
出版日: 26 April 2018
学会/ジャーナル: Neurocomputing
1. どんなもの?
副作用予測のためのmatrix factroizationの改良
2. 先行研究と比べてどこがすごい?
既存手法の精度向上
3. 技術や手法のキモはどこ?
医薬品の類似性による正則化項を追加
4. どうやって有効だと検証した?
CV using Liu's dataset (副作用はSIDERから取ってるので実質SIDER)
External validation using SIDER dataset after Liu's dataset construction
- top1000 predictionsを取ってきて、何個あたってるかで検証
20 runs of 5-fold CV
5. 議論はある?
パラメータはtestでベストなAUPRが出るものを使ってる
6. 次に読むべき論文は?
A Recommender System Approach for Predicting Drug Side Effects
基本情報
タイトル:A Recommender System Approach for Predicting Drug Side Effects
著者:
出版日: 8-13 July 2018
学会/ジャーナル: IEEE
1. どんなもの?
matrix factorizationを副作用予測に応用
2. 先行研究と比べてどこがすごい?
PPNに対して精度向上
3. 技術や手法のキモはどこ?
副作用予測を推薦問題と捉え、matrix factorizationを応用
4. どうやって有効だと検証した?
PR-AUC for hold-out test set.
Parameter tuning using 10-fold CV with train set.
5. 議論はある?
データ多くないのにhold-out
実際に予測が当たるのかSIDER以降のデータで検証した方が良さげ
6. 次に読むべき論文は?
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