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scclassify's Introduction

scClassify: hierarchical classification of cells

Single cell classification via cell-type hierarchies based on ensemble learning and sample size estimation.

Installation

Install Bioconductor packages S4Vectors, hopach and limma packages using BiocManager:

# install.packages("BiocManager")
BiocManager::install(c("S4Vectors", "hopach", "limma"))

Then install scClassify using devtools:

library(devtools)
devtools::install_github("SydneyBioX/scClassify")

Vignette and Shiny app

You can find the vignette at this webiste: https://sydneybiox.github.io/scClassify/index.html.

Also, you can find our interactive shiny application (beta) at this webiste: http://shiny.maths.usyd.edu.au/scClassify.

Pretrained models

Currently available pre-trained scClassify models (in scClassifyTrainModel class)

Tissue Organism Training Data Accession Summary Download .rds
Primary visual cortex mouse Tasic (2018) GSE115746 link link
Primary visual cortex mouse Tasic (2016) GSE71585 link link
Visual cortex mouse Hrvatin GSE102827 link link
Lung mouse Cohen GSE119228 link link
Kidney mouse Park GSE107585 link link
Liver human MacParland GSE115469 link link
Liver human Aizarani GSE124395 link link
Pancreas human Xin GSE81608 link link
Pancreas human Wang GSE83139 link link
Pancreas human Lawlor GSE86469 link link
Pancreas human Segerstolpe E-MTAB-5061 link link
Pancreas human Muraro GSE85241 link link
Pancreas human Baron GSE84133 link link
Pancreas human joint - link link
Melanoma human Li GSE123139 link link
PBMC human Ding (joint) - link link
Tabula Muris mouse Tabula Muris GSE109774 link link

Contact us

If you have any enquiries, espcially about performing scClassify to classify your cells or to build your own models, please contact [email protected] or [email protected].

Reference

scClassify: hierarchical classification of cells

Yingxin Lin, Yue Cao, Hani J Kim, Agus Salim, Terence P. Speed, Dave Lin, Pengyi Yang, Jean Yee Hwa Yang

bioRxiv 776948; doi: https://doi.org/10.1101/776948

scclassify's People

Contributors

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