A transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured

if(!require(devtools)) install.packages("devtools")
library(devtools)

devtools::install_github("JSB-UCLA/scDesign2")

This tutorial introduces how to use the scDesign2 R package, and can be directly used when trustworthy cell type information is available.

If not, then this tutorial can be read, which introduces how cell clustering can be performed and evaluated before using the scDesign2 method.

Sun, T., Song, D., Li, W.V. et al. scDesign2: a transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured. Genome Biol 22, 163 (2021). https://doi.org/10.1186/s13059-021-02367-2