Cell-cell communications via secreting and receiving ligands frequently occur in multicellular organisms, which is a vital feature involving numerous biological processes. Recent advancements in single-cell RNA sequencing (scRNA-seq) have effectively resolving cellular phenotype heterogeneity and cell-type composition of complex tissues, which enables systematic investigation of cell-cell communications at a single-cell resolution. However, the common practice to study chemical signal-dependent cell-cell communications with scRNA-seq relies heavily on the prior knowledge of ligand-receptor (LR) interaction pairs. Here, we introduce CellTalkDB, a comprehensive database of LR interaction pairs in human and mouse. By text mining and manual verification of known protein-protein interactions (PPIs) in STRING, CellTalkDB contains 3,231 human LR pairs and 1,941 mouse LR pairs with literature-supported evidence for each pair.

LR pairs in CellTalkDB can be also download in our website http://tcm.zju.edu.cn/celltalkdb

Raw data for reproduction of our results can be download in the release page.

Should you have any questions, please contact Xin Shao at [email protected]