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View Code? Open in Web Editor NEWThe Curation of Neurodegeneration Supporting Ontology (CONSO)
Home Page: https://pharmacome.github.io/conso/
License: Creative Commons Attribution 4.0 International
The Curation of Neurodegeneration Supporting Ontology (CONSO)
Home Page: https://pharmacome.github.io/conso/
License: Creative Commons Attribution 4.0 International
This is a metabolite of GTS-21 (HBP:HBP00310) but it seems to be a bit elusive when it comes to database entries.
Mentioned in pmid:25514383
See the "metabolism" section of https://www.drugbank.ca/drugs/DB05708
Awesome suggestion from @maestroe ๐
Appears in Mentioned in pmid:25514383
https://en.wikipedia.org/wiki/Leukotriene#Cysteinyl_leukotrienes
SET Evidence = "ABCC1: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]"
SET Subgraph = "Transport related subgraph"
p(HGNC:ABCC1) -| act(a(CHEBI:anticonvulsant))
# oxidized glutatione = glutathione disulfide
p(HGNC:ABCC1) -- tloc(a(CHEBI:"glutathione disulfide"))
#: Replace by future CHEBI term
# cysteinyl leukotrienes = leukotriene C4, D4, E4, F4
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene C(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene D(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene E(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene F(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"aflatoxin B(1)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
Inside OBO and OWL, we need a different relationship for BEL since they technically aren't cross-references
relations.tsv is checked assuming that all triplets contain only HBP terms but that's not the case
Suggestions from Johannes:
skos:altLabel
predicateskos:related
predicateTo merge the NESTOR database into the main HBP branch on GitLab, we need to:
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