Pulmonary drug absorption implemented in MoBi (Eriksson et al. 2020)

The presented model has been used for predictions of systemic exposure after drug administration via the lungs.

The predictive performances of the model were evaluated by comparing simulated plasma concentration-time profiles to clinical observations after pulmonary administration of drug in solution, as supension or as dry powder.

Schematic illustration of the alveolar and bronchial compartment and subcompartments in the physiologically based biopharmaceutics lung model developed in MoBi.

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

The model code is distributed under the GPLv2 License.

[1] Eriksson J, Thörn H, Lennernäs H, Sjögren E. Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling. Eur J Pharm Biopharm. 2020 Nov;156:191-202. doi: 10.1016/j.ejpb.2020.09.004. Epub 2020 Sep 15. PMID: 32941997.