open-systems-pharmacology Goto Github PK

rifampicin-verapamil-ddi

Modeling of published clinical Rifampicin-Verapamil-DDI studies for model evaluation

roadmap

Roadmap for the Open Systems Pharmacology Platform

rosuvastatin-model

Whole-body PBPK model of rosuvastatin (OATP1B1/OATP1B3/BCRP DDI victim drug)

s-mephenytoin-model

Whole-body PBPK model of s-mephenytoin as a substrate of CYP2C19

sglt2i-hyperfiltration-model

A Quantitative Systems Pharmacology kidney model of diabetes associated renal hyperfiltration and the effects of SGLT inhibitors.

sildenafil-model

skin-permeation-model

Implementation of Dancik et al (2013) skin permeation model in MoBi

sufentanil-model

Whole-body PBPK model of Sufentanil

sufentanil-pediatrics

suite

Open Systems Pharmacology Suite Setup

tacrolimus-model

tefibazumab-model

test-appveyor

Repository for testing purposes only

testcases

Test cases for the new OSP features

theophylline-model

Whole-body PBPK model of theophylline as CYP1A2 DDI victim drug

thyroid-hormones-pb-qsp-model

Physiology-based systems pharmacology model of thyroid hormones regulation in rat and human

tizanidine-model

Whole-body PBPK model of tizanidine as a substrate of CYP1A2

tlf-library

TLF Library implementation in R

tracelib

package to capture and store workflow traceability metadata

triazolam-model

Whole-body PBPK model of triazolam

trimethoprim-metformin-ddi

trimethoprim-model

trimethoprim-pioglitazone-ddi

trimethoprim-repaglinide-ddi

vancomycin-model

Whole-body PBPK model of Vancomycin

vancomycin-pediatrics

verapamil-midazolam-ddi

Modeling of published clinical Verapamil-Midazolam-DDI studies for model evaluation

verapamil-model

Verapamil PBPK model (parent only)

vision-mission

Vision & Mission of Open Systems Pharmacology

voriconazole-model

Whole-body PBPK model of voriconazole as CYP2C19 substrate and CYP3A4 perpetrator drug