nhejazi / pub_medshift_interv_biostats Goto Github PK

Code to reproduce the results reported in "Nonparametric causal mediation analysis for stochastic interventional (in)direct effects" by N.S. Hejazi, K.E. Rudolph, M.J. van der Laan, and I. Díaz in Biostatistics (2022)

• To reproduce the simulation study reported in the manuscript, examine the simulation subdirectory and the comments in the included README.md.
• To assess the data analysis results reported in the manuscript, examine the application subdirectory and the code it contains. The data from the X:BOT trial has not (yet) been released due to data sharing agreements; however, the exact R code applied to the dataset is included in this subdirectory.

Note that both directories reference the intmedlite auxiliary R package, which provides the estimation machinery used for the both the simulation studies and real-world data analysis. To support accessibility of the methodology, the functionality from this auxiliary package is presently in the process of being incorporated into our medshift package; this note will be updated to point to that functionality once initial integration and testing have been completed.

Should any concerns arise, please file an issue with a clear description of the problem encountered.