This is the repository belonging to the paper "The impact of the cardiovascular component and somatic mutation on ageing" by Garger et al.

The "Supplementary Table 1.xlsx" - "1j - Data for analysis" sheet contains the data which is used for the analysis.

• The CreateFigure.R file contains the code for executing the analysis of the paper. Furthermore, figures 2 & 3 and supplementary table 4 can be reproduced.
• Create_Figure_1_and_Supplementary_Figs.Rmd file creates the phylogenetic tree used for phylogenetic analysis, also creates a basic version of Figure 1 (final version created with Adobe Illustrator), and also all Supplementary Figures along with required analysis (phylogenetic regression, bootstrapping analysis).

We used R 4.1.2 and the following libraries for the analysis:

• readxl
• ggplot2
• tidyverse
• ggrepel
• reshape2
• broom
• ppcor
• scatterplot3d
• factoextra
• FactoMineR
• PCAtools
• boot
• ape
• ade4
• dplyr
• caper
• nlme
• gridExtra
• phytools
• colorspace
• ggpubr
• lemon
• gplots
• devtools
• ggtree
• cowplot
• colorspace
• ggplotify
• ComplexHeatmap
• writexl