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liuxch5's Projects

adjutant icon adjutant

Runs a pubmed query, returns results and allows user to explore high-level structure of returned documents

ai-blog icon ai-blog

Repository for the RStudio AI Blog (formerly: TensorFlow for R Blog)

altre icon altre

ALTered Regulatory Elements

analyzer icon analyzer

An R Shiny app that accepts a CSV file with data, and outputs high level regression analysis.

atlantic icon atlantic

Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action. We extend this paradigm to measuring proteome activity landscapes by acquiring and integrating quantitative data for 10,000 proteins and 55,000 phosphorylation sites (p-sites) from 125 CCLs. These data are used to contextualize proteins and p-sites and predict drug sensitivity. For example, we find that Progesterone Receptor (PGR) phosphorylation is associated with sensitivity to drugs modulating estrogen signaling such as Raloxifene. We also demonstrate that Adenylate kinase isoenzyme 1 (AK1) inactivates antimetabolites like Cytarabine. Consequently, high AK1 levels correlate with poor survival of Cytarabine-treated acute myeloid leukemia patients, qualifying AK1 as a patient stratification marker and possibly as a drug target. We provide an interactive web application termed ATLANTiC (http://atlantic.proteomics.wzw.tum.de), which enables the community to explore the thousands of novel functional associations generated by this work.

awesome-r icon awesome-r

A curated list of awesome R packages, frameworks and software.

checkmyindex icon checkmyindex

Search for a set of compatible indexes for your sequencing experiment

chippcr icon chippcr

Toolkit of helper functions to pre-process amplification data

chordomics icon chordomics

Interactive visualisation and data annotation for meta-omics data

clusterprofiler icon clusterprofiler

:bar_chart:statistical analysis and visualization of functional profiles for genes and gene clusters

cn_mooc_dl icon cn_mooc_dl

**大学MOOC,学堂在线,网易云课堂,下载

data606 icon data606

Statistics and Probability for Data Analytics

ddpcrclust icon ddpcrclust

A package for automated quantification of non-orthogonal, multiplexed ddPCR data

desktopdeployr icon desktopdeployr

A framework for deploying self-contained R-based applications to the desktop

deviumweb icon deviumweb

Interactive multivariate data analysis in R implemented in shiny.

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