This repo contains an Aspen Plus-Python connection example.
Differently from Aspen-HYSYS, accesing the variable paths in Aspen Plus is very straight forward. Therefore, the connection can be made directly easily (without the spreadsheets trick of the Aspen_HYSYS_Python repo).
The code is just a couple of lines long that are self-explanatory and have comments too.
This is an example of where you might want to look for the variable paths of interest:
This repository contains a MIT LICENSE