In general I recommend very conservative usage of immaterial entities, there are all kinds of OWL traps in using them

There are some particular problems here:

• anus is treated as a space which is incompatible with the most widely used insect anatomy
  Dmel anus cc
• chambers such as the genital chamber are treated as structures not spaces in uberon fbbt etc
• in fact in your own definition of genital chamber you say it is a region

Also, if you are following philosophical upper ontologies and dividing material and immaterial entities I recommend adding disjointness axioms to detect any problems early lmk if you want help with this (reasoning with uberon should also do this)

cuticular internal depression

SubClassOf:
'region of cuticle'
and ('part of' some 'proximal side')
and ('bearer of' some concave)
'part of' some 'insect region of integument'
'part of' some 'chitin-based cuticle'

I strongly recommend that all subclass axioms are written in equivalent form that dosn't use IntersectionOf

1. CID subClassOf 'region of cuticle'
2. CID 'part of' some 'proximal side'

This is equivalent and will make your ontology much more usable to any consumer that is not using a reasoner

I believe running https://robot.obolibrary.org/relax should take care of this - if you are using a standard ODK template not sure why we are not seeing the simplified form