hincz-lab / microrna Goto Github PK

Numerical calculations and plotting routines related to the article: "Bioenergetic costs and the evolution of noise regulation by microRNAs" (https://doi.org/10.1101/2023.03.28.534633) by Efe Ilker (https://github.com/eilker) and Michael Hinczewski

Description of files:

• Noise filter calculations for Figs 2 and 3.nb: Mathematica notebook containing calculations relating to the noise filter analysis of the microRNA network.
• fig2, fig3: Directories containing the data generated by the above notebook.
• Plotting routines for Figs 2 and 3.ipynb: Jupyter notebook to generate Figures 2 and 3 using Python matplotlib.
• KD analysis/MiRNA KD analysis.nb: Mathematica notebook for the dissociation constant analysis (Fig. S2)
• KD analysis/miR_Family_Info.txt: Seed sequences from TargetScanHuman database v.7.1 (https://www.targetscan.org/vert_71/)
• figS1: directory with data for Fig. S1