Simplistic TypeScript empty project:

• Install node.js:

  • on Ubuntu: sudo apt-get install nodejs-legacy
  • on Mac with Homebrew: brew update && brew install node

• To start developing, just type:

  # Install dependencies locally
  npm i
  # Starts a server with live-reload, and recompiles files when they're saved:
  npm start

• To build a self-contained deployable artefact (build/index.html):

  npm run build
  

About this setup:

• TypeScript with strict settings (null-awareness, no implicit any, no implicit returns) and down-compilation to ES5
• Optimized bundle creation with Rollup + Uglify
• Immutable.js import to get you started with decent collections :-)
• Inlines all .js into build/index.html when running npm run build

What it does not do:

• No Angular2 setup. It's not ready yet for --strictNullChecks and has its own command line tool anyway.
• No React / Flux setup. Should be easy to use, though.