Comments (1)
gatsby2016
commented on June 17, 2024
- 分析1：修改现有euclidean为标准化没有意义，因为对于某个样本来说，某个gene可能的确是marker gene，进而导致在该样本下gene expression value higher but lower in other cells. 同时其他gene的expression lower。
- 分析2：spearman相关系数对分量排序离散化，可以理解为筛选当前cell的marker gene 同时确定pairwise的cell是否也具有同样趋势； 所以这么看也有道理。
是不是可以，把kmeans结果之后CSPA之前的multi-res直接ARI分析一下，这样确定哪些特征组合更优？再进行优化？or, can we assign weights to each res in multi-res for CSPA?
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