The framework of computational drug repositioning is an integration of molecular network-based approach and pharmacoepidemiologic method, witch includes the following steps (shown as figure):
- collection of disease-related genes;
- collection of available drugs;
- screening drugs by their proximity to disease-related genes on the interactome network;
- filtering the screened drugs based on their correlation with gene expression profiles.
Relevant paper has been published in Bioinformatics.