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Introduction

Acute Myeloid Leukemia (AML) is a cancer of myeloid lineage cells in blood. Here, we’re collecting a list of papers, reviews, and possibly applications related to AML.

Good start

Manuscript Link
Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies Journal of Oncology, 2019
Single-Cell RNA Sequencing to Disentangle the Blood System Arteriosclerosis, Thrombosis, and Vascular Biology, 2021
Hematopoietic Stem Cell: Self-renewal versus Differentiation Wiley Interdiscip Rev Syst Biol Med., 2010

Generic Classifications

Manuscript Link
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/ Dendritic Neoplasms Leukemia, 2022
World Health Organization classification of myeloid neoplasms and acute leukemia Blood, 2016
Genomic Classification and Prognosis in Acute Myeloid Leukemia N Engl J Med, 2016
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel Blood, 2017
Validation and refinement of the revised 2017 European Leukemia Net genetic risk stratification of acute myeloid leukemia Leukemia, 2020

Bulk Transcriptomics

Manuscript Link
Mapping AML heterogeneity - multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses Leukemia, 2024
A transcriptomic based deconvolution framework for assessing differentiation stages and drug responses of AML NPJ PO, 2024
A 17-gene stemness score for rapid determination of risk in acute leukaemia Nature, 2016
A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia Nature Comm., 2021
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia Nat Med., 2022
Functional genomic landscape of acute myeloid leukaemia (BEAT-AML) Nature, 2018
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia Cancer Disc., 2020

Single-cell Transcriptomics

Manuscript Link
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity Cell, 2019
A single-cell survey of cellular hierarchy in acute myeloid leukemia Journal of Hematology & Oncology, 2020
Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression Leukemia, 2021
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing Nature Comm., 2019
Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics iScience, 2020

Single-cell Multiomics

Manuscript Link
Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia Cell Stem Cell, 2023
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states Nat Immun., 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics Nature Comm., 2021
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia* Nature Biotech., 2019

Epigenetics

Manuscript Link
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution* Nature Gen., 2016

Flow Cytometry

Manuscript Link
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes Leukemia, 2012

DNA

Manuscript Link
Single-cell mutation analysis of clonal evolution in myeloid malignancies* Nature, 2020
The Origin and Evolution of Mutations in Acute Myeloid Leukemia Cell, 2012

Subtype-spesific

NPM1

Manuscript Link
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML Nature Comm., 2021

* might not be exactly AML but leukemia

Contributions

PRs are more than welcome and encouraged!

Note: I am mostly interested in transcriptional and epigenetic changes in AML at single-cell scale, thus making the repo biased towards related papers.

  1. Fork this repository
  2. Make a change to README.md
  3. Submit a pull request.

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