This page contains:

(1) The copy number tables from in vitro cell line mixtures, generated to evaluate the accuracy of liquidCNA, a method for tracking emergent subclone dynamics in CNA data from longitudinal biopsies. The tables hold raw and segmented copy number information (generated using QDNAseq) from the two high-grade serous ovarian cancer cell lines (B0, B1), from healthy blood (N0) and 6 mixtures samples (S0-S5).

(2) The list of putatively therapy-associated (subclone-associated) COSMIC genes in cfDNA samples of patients undergoing therapy. The tables of each patient contain the copy number of each gene in baseline and post-baseline samples, together with the direction of the associated post-baseline SCNA identified by Chen and colleagues in the original study (-1: losses, +1: gains, 0: not highlighted by Chen et al.)

For details on data generation and downstream analysis, see our preprint (Lakatos et al., 2021) on bioRxiv.

For further details on the method, see liquidCNA's github page.