duveychan1 / vgckimo Goto Github PK

#VGC-KiMo v2015.04.23 ####Voltage-Gated Ion Channels Kinetic Modeling For Whole-Cell Voltage-Clamp Recordings

VGC-KiMo software allows for kinetic modeling of voltage-gated ion channels using whole cell voltage-clamp data. Sets of data from various experimental voltage protocols are analyzed simultaneously and fitted to Markov chain models. The minimization procedure allows to assess the right model and the corresponding kinetic parameters that describe the channel kinetics. In the current form, the source code includes a Markov formulation for the Kv11.1 or hERG K+ channel. Any other ion channel could be added to the source code in addition to the current one, different Markov models and other voltage protocols.

• Pablo M. De Biase ([email protected])
• Laura L. Perissinotti ([email protected])

If you use this program please site us:

1. Kinetic Model for NS1643 Drug Activation of WT and L529I Variants of Kv11.1 (hERG1) Potassium Channel Laura L Perissinotti, Jiqing Guo, Pablo M De Biase, Colleen E Clancy, Henry J Duff, Sergei Y Noskov, Biophysical Journal (Impact Factor: 3.83). 03/2015; 108(6):1414-1424. DOI: 10.1016/j.bpj.2014.12.056

• doc - Documentation, license, figures, release
• src - Sources and compiler script
• bin - binary files
• tutorial - Examples, test and tutorial document