dsi-icl / optimise Goto Github PK

This is a request from the Oxford group. Requirement for more identifiers that can be used for research purposes.

Button 'Other' for treatment category is not functional on SHOW's version. This is functional in candidate fixes-oxford-april branch commit f532264.

This is a request from SHOW.

Note that Visits and Clinical Events currently share the same Signs and Symptoms options.

Should Oscillopsia be moved from Signs to Symptoms?

Request from SHOW.

If Vibration Loss is required as an option, how (form of input) and where in Visits should we add it?

Where and how should double vision be implemented? Signs, symptoms or both?

Further clarification as to how this feature should be implemented is required. Current options for Brain and Spine Morphology are shown in the screenshots below. Would the new feature be available as an option? How will we indicate the comparison ('no change' compared to which MRI)?

Request from SHOW.

If RAPD is to be added, what is the input type and where in Visits should we add this?

Response from Paul Matthews to Oxford request for an e-cigarette option:

Ignore

We addressed the request for adding the option- see issue #3

Request from SHOW.

Where in Tests and how (input box, list of options?) will this be implemented?

Request from SHOW.

Current CSF results section is shown below. How should this option be implemented?

Data is automatically saved once entered in the following sections:

• Profile > Demographic
• Visits
• Clinical Events
• Tests
• Treatments (excluding Drug Interruptions)
• Reminders

There is a Save/Add feature for the following:

• Profile > Medical History
• Profile > Family Medical History
• Profile > Primary Diagnosis (excluding Basis of Diagnosis tool)
• Treatments > Drug Interruptions

We will consider adding a Save/ Confirmation feature for any data entered. We have to take account user role-based rights issue #28 when implementing this.

Request from SHOW.

If Romberg’s sign is to be implemented, where should we add this and what form of input will it accept?

Dates for Visits, Clinical Events, Tests and Treatments cannot be changed once entered unless the whole entry is deleted.

Should we enable the user to change the date after creating an entry in these sections?

Request from SHOW.

Will the Red cell count option be implemented?

Request from SHOW.

Current options for Bladder in candidate fixes-oxford-april branch commit f532264 are shown below. Are these satisfactory?

Signs section in Visits is not functional.

Request from SHOW.

If this is to be implemented, where in Symptoms should the option for balance problems be added? Current symptom options are shown in the screenshots below.

Request from SHOW. This is not available in candidate fixes-oxford-april branch commit f532264.

Is the proposed solution shown below satisfactory? If the user clicks Detected, Paired and Unpaired buttons become available. What is the appropriate CDISC field to store this additional information (Paired/Unpaired)?

Implementation of user role-based rights such as data update and deletion right.

• Who will have access to the application?
• How will user accounts be created/ assigned?

Clicking 'View all reminders' shows no reminders even though there are clearly reminders set for at least one patient.

We need to define 'consent' here. Consent for patient data to be shared for research purposes or for patient data to be stored? In the current version, consent is set by the user when they create a new patient. The CDISC field RFICDTC is set to the date/time the patient is created if patient gives consent or to an empty string otherwise. Date of initial consent is currently the only information stored. It is not possible to update consent in current version.

Need to consider who can update consent, who can delete data if consent removed, which CDISC standards can be implemented and how. Related issues #28 and #30.

Request from SHOW.

Note that Visits and Clinical Events currently share the same Signs and Symptoms options.

Should Atypical facial pain be moved from Signs to Symptoms?

Request from SHOW.

Please can you clarify. What changes in the current EDSS tool shown below do you suggest?

Remove Yes/No buttons from Recovery input.

Further information about where and how this option should be implemented. Is Spasms a Sign or a Symptom or both?

SHOW users cannot enter any data for Spine imaging. This is functional in candidate fixes-oxford-april branch commit f532264.

Current treatment list (treatment name and treatment category):

- name: 'Alemtuzumab (Lemtrada)', cat: 'Disease Modifying'
- name: 'Avonex (Interferon beta-1a)', cat: 'Disease Modifying'
- name: 'Azathioprine', cat: 'Disease Modifying'
- name: 'Betaferon (Interferon beta-1b)', cat: 'Disease Modifying'
- name: 'Cladribine (Mavenclad)', cat:'Disease Modifying'
- name: 'Cyclophosphamide', cat: 'Disease Modifying'
- name: 'Daclizumab (Zinbryta)', cat:'Disease Modifying'
- name: 'Dimethyl fumarate (Tecfidera)', cat:'Disease Modifying'
- name: 'Extavia (beta interferon-1b)', cat: 'Disease Modifying'
- name: 'Fingolimod (Gilenya)', cat:'Disease Modifying'
- name: 'Glatiramer acetate (Copaxone)', cat: 'Disease Modifying'
- name: 'Methotrexate', cat: 'Disease Modifying'
- name: 'Mitoxantrone', cat: 'Disease Modifying'
- name: 'Natalizumab (Tysabri)', cat: 'Disease Modifying'
- name: 'Plegridy (peginterferon beta-1a)', cat: 'Disease Modifying'
- name: 'Rebif (beta interferon-1a)', cat: 'Disease Modifying'
- name: 'Rituximab', cat: 'Disease Modifying'
- name: 'Teriflunomide (Aubagio)', cat:'Disease Modifying'
- name: '4-aminopyridine', cat: 'Symptomatic'
- name: 'Corticosteroids', cat: 'Symptomatic'
- name: 'Prednisone', cat: 'Symptomatic'
- name: 'Amantadine', cat: 'Symptomatic'
- name: 'Baclofen', cat: 'Symptomatic'
- name: 'IV Methyl-prednisolone', cat: 'Symptomatic'
- name: 'IVIG', cat: 'Symptomatic'
- name: 'Plasma Exchange', cat: 'Symptomatic'
- name: 'Mycophenolic Acid', cat: 'Symptomatic'
- name: 'Neuropsych. Training', cat: 'Others'
- name: 'Physiotherapy', cat: 'Others'
- name: 'Cognitive Therapy', cat: 'Others'

Is the treatment list complete and accurate?

SHOW team suggested recording information about who is seeing a patient at each visit might be useful. Possible options include doctor, nurse and consultant.

Further information about the implementation of this tool is required. Is there a CDISC field to store this information? Will the user select from a list of available options (in which case we need the list of options) or the input will be free text?

What is the proposed solution?

MRI for both Brain and Spine for a particular date can be added using the 'region' drop-down list. However the user cannot create two MRI entries with the same date. Would it be a good idea to allow the user to have more than one MRI for the same date?

Feedback from Oxford: "The MS research team do not appreciate the graphics, particularly the circles on the timeline. There is no capacity to hover over the icons for clinic dates or relapses and have information about the episodes such as actual dates, steroids, or even the type of clinic such as DMT clinic, nurse clinic, and relapse clinic...The primary diagnosis does not appear on the timeline."