RIC is a package that contains a number of functions to analyse RNA-bound proteins detected in on oligo-DT-mediated RNA capture experiments. The package contains published SILAC data published by Garcia-Moreno et al 2019 processed with MaxQuant and follows the analytical steps described by Perez-Perri et al 2020.

Once installed, load the package by writing in the console

library(RIC)

Please see the vignette for complete workflow description.

For references about the software and how to use RIC data see:

• Joel I Perez-Perri, Marko Noerenberg, Wael Kamel, Caroline E Lenz, Shabaz Mohammed, Matthias W Hentze, Alfredo Castello. Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture Nat Protocol. 2021 Jan;16(1):27-60. Epub 2020 Nov 18. (https://doi.org/10.1038/s41596-020-00404-1)