Title: Association between metformin use and transformation of monoclonal gammopathy of undetermined significance to multiple myeloma in U.S. veterans with diabetes mellitus: a population-based cohort study

Authors: Su-Hsin Chang, PhD; Suhong Luo, MS; Katiuscia K. O’Brian, MA; Theodore S. Thomas, MD; Graham A. Colditz, DrPH; Nils P. Carlsson, BS; Kenneth R. Carson, MD

This study examined the association between the diabetes drug metformin and the progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM), finding a protective association. Data from an observational cohort of U.S. Veterans were used. My primary responsibility was creation of the algorithm that classified patients as metformin users, as inconsistent usage patterns were prevalent in the cohort. My algorithm, written in SAS, was designed to identify consistent users, so that the biological effect of metformin would be accurately represented in our statistical analyses. Please see below for a link to the full text of the article.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448731/