Simple model to study the mRNA turnover kinetics

Author: Anna B. Matuszyńska

In this repository we explore the ideas presented in the original work by Hargrove and Schmidt [1] and White, Brewer and Wilson [2] on the effect that changing the rate of synthesis and degradation of mRNA would have on the final concentration. We play with the simplest, well established mathematical model based on a single compartment, with zero-order rate kinetics for mRNA synthesis and first-order rate of decay.

Included files aims at further supporting hypotheses generated by Srimeenakshi Sankaranarayanan, Carl Haag, Patrick Petzsch, Karl Köhrer, Kathi Zarnack and Michael Feldbrügge in their manuscript.

[1] Hargrove,J.L.; Schmidt, F. H. The role of mRNA and protein stability in gene expression. FASEB J. 3: 2360-2370; 1989.

[2] White, E.J.F.; Brewer, G.; Wilson, G.M. Post-transcriptional control of gene expression by AUF1: Mechanisms, physiological targets, and regulation. Biochim Biophys Acta. 1829(0): 680–688; 2013.