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2p-olfactory-code-analysis's Introduction

2p-Olfactory-Code-Analysis

Collaborated work by Kaining Zhang, Pingchuan Ma, Binxu Wang

Trial structure

Trial structure : for each stimuli 40ms before start, 15ms during stimuli, 60ms after stimuli.

TODO List

  • Examine the Odor and their natural functions

    • Odor and their receptor and their pathway
    • EA, EB, MH are similar chemical (ester) is food odor
    • 1-octen-3-ol
    • Bzald (Benzaldehyde), Acet (Acetophenone)
  • Response matrix

  • draw a distribution of the responsive neuron on z axis.

  • Matrix factorization

    • SVD (KN)
    • Non negative matrix factorization (NMF) (BX)
  • classify neuron based on their response to stimulus.

    • Hierachical clustering??? (based on distance) (BX)
    • K means (On response/off response ; PCA Dimension reduction ) (KN)
    • Plot cluster distribution on z axis
  • Draw the neurons population trajectory to the stimuli.(have done) (KN)

    • SVD
    • LLE / Other non linear dimension reduction
  • Background research

    • Anatomical location
    • connectivity ~ Antennal lobe, Mushroom Body
      • Laminar structure?????
    • Computational function??????? (Expansion / compression????)
    • Function in sensory transformation ?

Spatial Temporal Structure of Lateral Horn Input

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