const emulator = new Emulator(Uint8ArrayNESData, {
  onFrame: frame => {
    ... // output image
  },
  onSample: volume => {
    ... // output audio
  }
});

document.addEventListener('keydown', e => {
  ... // analyse key board code 
  emulator.standardController1.updateButton(StandardControllerButton.A, true);
});

setInterval(() => {
  emulator.frame();
}, 16);