Comments (4)
Thanks for your feedback!
- The issue seems to have arisen during plotting, there may be some problems with some of your input samples, please try the following code to identify which samples have weird mAge predictions: PCGrim=methyAge(beta_raw, clock="PCGrimAge",age_info = info,fit_method='Linear', do_plot=FALSE)
- There is no recommended normalization step, my advice is to use the same normalization method if you want to compare mAge prediction between clocks.
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Hi,
Thanks so much for your help! I tried do_plot=FALSE and got a different kind of error:
Error in $<-.data.frame
(*tmp*
, "Age_Acceleration", value = c(1
= -2.06246174972107, :
replacement has 1027 rows, data has 1039
I double checked and both the "beta_raw" and "info" data frames have 1,039 observations. The same code worked for other clock (eg Hannum), either with do_plot=TRUE or FALSE...
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If you do not mind, please send me a subset of your input data so I can do better troubleshooting.
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Turned out there were some NA values in the CpG sites. It is working now after dropping NA. Thank you!
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Related Issues (13)
- add PedBE clock HOT 1
- PC clocks not showing up when running availableClock() HOT 4
- add golden ref value for missing probes HOT 2
- add epiTOC2 HOT 1
- need quantile normalized into fixed reference
- PCGrimAge with more CpGs than the original clock? HOT 2
- Is PCGrimAge still available in dnaMethyAge? HOT 5
- Got Error message for Infinium MethylationEPIC v2.0 Kit Error in density.default(beta2.v[which(beta2.v < 0.4)]) : need at least 2 points to select a bandwidth automatically HOT 4
- Negative values for PhenoAge Clock HOT 1
- Overestimates of HorvathS2018 and Hannum clocks HOT 1
- Error in density.default(beta2.v[which(beta2.v < 0.4)]) : need at least 2 points to select a bandwidth automatically HOT 1
- Request for all publications on available clocks HOT 4
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