Comments (3)
Hi Wei,
Thanks for that. I have another question. You mentioned that M is the pruned markers used for estimating the genetic relationship matrix. I would like to know when you pruned the markers, what kind of parameters did you set to get 93, 511 markers?
Best wishes,
Yeda
from saige.
Hi Yeda,
The 93,511 markers are markers included by the UK Biobank for kinship estimation. The standard used for the selection can be found in this paper
https://www.biorxiv.org/content/early/2017/07/20/166298
Thanks,
Wei
from saige.
Hi Yeda,
PCs are still needed as covariates to account for population stratifications.
Thanks,
Wei
from saige.
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