can we use CellChat for user-specific custom interactions? about cellchat HOT 4 CLOSED

Hi @jv-20 , here is an example for inferring interactions for TGFb signaling signaling.show <- c("TGFb") pairLR <- searchPair(signaling = signaling.show, pairLR.use = cellchat@LR$LRsig, key = "pathway_name", matching.exact = T, pair.only = F) cellchat <- computeCommunProb(cellchat, LR.use = pairLR)

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@jv-20 Please check the previous issues #20 and #38 to see how to update the database.

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Thanks so much for the reply. That's helpful. I have another question. For example, if we know hypothetically there are other potential receptors for a specific ligand but it is not reported in the cellchatDB, is it possible to add these interactions to the database and run the pipeline?

Thank you,
Janaki

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Excellent 👏 thanks for the links. I will follow the instructions to update the database. Thank you again for your kind reply 🙏

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