sambryce-smith Goto Github PK

I'm a final year bioinformatics PhD student studying amyotrophic lateral sclerosis (ALS) in the labs of Prof Pietro Fratta & Dr Maria Secrier at UCL. I mainly focus on bioinformatic analysis of alternative polyadenylation with RNA-seq data, especially bulk short-read RNA-seq and Nanopore long-read sequencing. Generally very interested in using sequencing approaches to understand how RNA-binding proteins influence the transcriptome and taking any opportunity to build Snakemake pipelines!

Due to submit PhD thesis in July 2024 - open to job opportunities in Belgium (from October 2024)!

Currently working on:

• PhD thesis (!)
• Novel methods for identifying, quantifying and assessing differential usage of polyA sites from bulk RNA-seq data (watch this space!).
• APAeval - a community project to develop a framework for reproducible benchmarking of bioinformatic algorithms and assess the performance of tools that identify and/or quantify polyA sites from bulk RNA-seq data.