{
    "page": 1,
    "numberPages": 11,
    "targets": [
        {
            "target_id": 158,
            "target_name": "SGLT2",
            "actions": [
                {
                    "action_id": 2,
                    "action_name": "Activators",
                    "alerts": [
                        {
                            "affected_system_id": 10015919,
                            "affected_system": "eye disorders",
                            "adverse_event_id": 10015916,
                            "adverse_event": "eye disorder",
                            "ref_id": 62872,
                            "ref_source_type": "Journal",
                            "ref_title": "Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use",
                            "ref_citation": "Drug Saf 2020 Feb 28",
                            "ref_pubmed_id": "32112228",
                            "ref_link": null,
                            "ref_date": "2020-02-28",
                            "alert_detail_id": 662867,
                            "alert_title": "Phenome-wide association study identifying human gene mutations that could be used for in silico prediction of potential adverse drug effects. Results revealed 8 positive associations correlating gene mutation phenotypes with known safety signals from drugs targeting the protein. These associations were PCSK9 (spina bifida), TNF-alpha (cellulitis and leg abscess), PPARgamma (obesity), estrogen receptor-alpha (hemorrhages), ACE (congenital urinary anomalies), phospholipase A2 (primary hypercoagulable state), GluN2B (symbolic dysfunction) and GluN2A (paroxysmal tachycardia, pulmonary heart disease and sleep disorders). Other safety issues are listed.",
                            "alert_date": "2020-03-11",
                            "alert_genetic_study_variant": "gain-of-function mutation",
                            "alert_type": "Class Alert",
                            "alert_phase": "Target Discovery",
                            "alert_onoff_target": "On-Target",
                            "alert_level_evidence": "Suspected",
                            "alert_severity": "no",
                            "alert_species": "human",
                            "drugs": []
                        }
                    ]
                }
            ]
        }
    ]
}