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nhejazi avatar nhejazi commented on July 24, 2024

For now, it's best to remove the outcome option in the main biomarkertmle function. In future, we can consider ways to approach this -- with the most obvious idea being to estimate a different parameter entirely (than the ATE), perhaps using the tmle.npvi package.

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nhejazi avatar nhejazi commented on July 24, 2024

It seems that the implementation of a TMLE for a target parameter interpretable as the counterfactual value of the outcome of interest under a posited shift of the observed treatment value, available in the txshift R package, could be useful for this purpose.

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nhejazi avatar nhejazi commented on July 24, 2024

At the present, implementing such an extension of the methodology appears to be outside the scope of this R package.

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nhejazi avatar nhejazi commented on July 24, 2024

Outside the scope of this package. An equivalent shrinkage-based variance estimator should likely be implemented separately in other packages so as to better make use of each of their (likely very different) APIs.

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