Single amino acid polymorphisms about msfragger HOT 5 OPEN

We may add PEFF support at some point, http://www.psidev.info/peff but that will take time You should just built your own custom database and search that. And note that a bigger issue is not the searching itself, but FDR estimation for variant peptides. Best Alexey

I certainly would not argue with that but we need to do the work to support PEFF format, or read another file (which may include PTMS as well) It’s a question of effort at this point… From: Andrey Rozenberg [mailto:[email protected]] Sent: Tuesday, October 15, 2019 2:04 PM To: Nesvilab/MSFragger <[email protected]> Cc: Nesvizhskii, Alexey <[email protected]>; Comment <[email protected]> Subject: Re: [Nesvilab/MSFragger] Single amino acid polymorphisms (#44) External Email - Use Caution Thanks for the prompt response! A custom database is of course an option, but with the drawback you mention. I think, in a future solution, polymorphisms should be treated basically the same way modifications are. — You are receiving this because you commented. Reply to this email directly, view it on GitHub<#44?email_source=notifications&email_token=AIIMM62NR2V3LSMORG2JFTLQOYAX3A5CNFSM4JA4GWBKYY3PNVWWK3TUL52HS4DFVREXG43VMVBW63LNMVXHJKTDN5WW2ZLOORPWSZGOEBJV7TI#issuecomment-542334925>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/AIIMM62ZICHHTYHA62U7WETQOYAX3ANCNFSM4JA4GWBA>. ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues