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Name: Jenna Tomkinson

Type: User

Company: University of Colorado Anschutz Medical Campus

Bio: Quantitative Cell Biologist in the @WayScience lab in the Department of Biomedical Informatics

Twitter: jenna_tomkinson

Location: Aurora, CO

Hi there! Welcome to my profile šŸ¤—

I am a young computational biologist šŸ‘©šŸ»ā€šŸ’», just trying to find her place in the world šŸŒŽ

  • šŸ”­ Iā€™m currently working on multiple image-based analysis projects in the Gregory P. Way lab.
  • šŸŒ± Iā€™m currently learning how to grow my knowledge of Python and R. One of my biggest goals is to improve my biostatistics and machine learning skills.

Jenna's GitHub stats

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My current projects

If you are curious about the projects I am working on, here is a list of the repositories:

  1. NF1 Cell Painting Project - Image analysis and image-based profiling of Schwann cells of different genotypes (WT, Null, and HET) to identify a biomarker.
  2. CFReT Project - Image analysis, image-based profiling, and machine learning to predict healthy or failing cell types of cardiac fibroblasts.
  3. Pyroptosis Signature Project - Image analysis and image-based profiling of PBMCs and SHSY-5Ys to use in cell death prediction.

Publications

We submitted a preprint for our project titled "Toward generalizable phenotype prediction from single-cell morphology representations". This paper describes our work to make a generalizable model predicting phenotype based on nucleus features utilizing the Mitocheck 2015 labeled dataset. We applied this model to the JUMP consortium and performed a Leave One Image Out analysis, discovering that many features are variable across datasets, leading to problems with generalizability. We propose different steps to solving this issue within our discussion.

Jenna Tomkinson's Projects

cell-health-data icon cell-health-data

Data processing for the Cell Painting data from the Cell Health experiments

cellprofiler_prototyping icon cellprofiler_prototyping

This repository contains CellProfiler pipelines testing various steps within a cell image analysis pipeline.

ic_test icon ic_test

This repository holds all of the research and code used to develop IC Test.

idr_stream icon idr_stream

Software for feature extraction from IDR image data

nf1_cellpainting_data icon nf1_cellpainting_data

This repository contains all the modules to perform image-based analysis with CellProfiler on NF1 Schwann cell data.

nf1_project_figure icon nf1_project_figure

The pipeline used to create the figure for the NF1 grant uses code from https://github.com/jr0th/segmentation/blob/master/visualization/CellArt.ipynb

pycytominer icon pycytominer

Python package for processing image-based profiling data

pyroptosis_signature icon pyroptosis_signature

This repository contains the pipelines used to analyze the data sets from the Interstellar collaboration.

sandbox icon sandbox

A place to mess around learning github

scupltqc icon scupltqc

SCulptQC is a software tool for single-cell quality control of morphology datasets.

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