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tonydisera avatar tonydisera commented on July 29, 2024

In particular, there is a de novo variant in gene SPRX that is in the 'slivar prioritized variant'. When gene.iobio is launched with the variant set, this variant shows up under 'filtered variants', meaning it didn't pass any of the standard filters, which is odd, b/c it does seem to pass the 'De novo' filter criteria. Then, if I click on the gene in the genes panel, the variant moves under the 'De novo variants' filter.
You can try this by launching with the 'Tony - troubleshooting SPRX' variant set.

from gene.iobio.

tonydisera avatar tonydisera commented on July 29, 2024

So we know there are a few problems here:

  1. The filters should be sorted based on the way they are originally ordered on a fresh launch of gene.iobio. This order is not being maintained when launching a saved analysis.
  2. The 'filtered variants' (variants in variant set, but not passing any of the gene.iobio filters) are getting lost after saving analysis. These variants need to be restored when the saved analysis is launched
  3. There is an inconsistency in how a variant is passing a filter when launched from a variant set vs when the gene is clicked.

from gene.iobio.

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