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jeffreyruffolo avatar jeffreyruffolo commented on August 10, 2024

Hello, it looks like you are trying to pass in too much of the antibody sequence. Specifically, here it looks like your sequence is ~240 residues, so I would guess it is the variable fragment plus the first conserved domain.

For IgFold, the expected input is just the variable fragment. If I truncated the sequence to
QMKLMQSGGVMVRPGESATLSCVASGFDFSRNGFEWLRQGPGKGLQWLATVTFESKTHVTASARGRFTISRDNSRRTVYLQMTNLQPDDTAMYFCVKDQTIFHKNGAVDFFSYFDLWGRGAPVIVS
it looks reasonable.

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Demoyhy avatar Demoyhy commented on August 10, 2024

Thank you for your answer, it is indeed done in this way. I also want to ask you a question, is igfold can be used to predict the structure of antigens? Do you have any suggestions for this

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