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Vincent-Ustach avatar Vincent-Ustach commented on August 16, 2024

The HPO is a directed graph that points from the leaf terms to the phenotype root term "HP:0000118- Phenotypic Abnormality" which points to "HP:0000001- All."

Therefore the HPO is flipped over in a way- nx.ancestors(G, source) returns all nodes having a path to the node source in the graph G which are the child terms aka farther away from root.

@arvkevi, we could look at the diseases annotated to each node and see how they populate cumulatively from leaf to root. This would give us a good idea of how to answer @krttrr 's question.

from phenopy.

krttrr avatar krttrr commented on August 16, 2024

Great, I was hoping I was wrong!

Let me know how the other question shakes out...

from phenopy.

Vincent-Ustach avatar Vincent-Ustach commented on August 16, 2024

closing this.

@krttrr the IC is inherited from parents (closer to the root), not from children (closer to leaf nodes), so the answer to your first question is: no.

from phenopy.

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